Sensing the Tension: Identifying Mechanotransducers That Regulate Muscle Growth reviews thefact that nearly all cells in the body are exposed to a wide variety of external mechanical forcers,including tension (which causes deformation of the cell), compression (a pushing force that takesplace perpendicular to the cell), and shear stress (which occurs parallel to the surface membraneof the cell). Featuring five highly respected professionals, the DVD discusses several of the keyfactors involved in the process of cellular mechanotransduction, in which these forces areindividually and collectively are converted into a chemical signal that then allows for changes intranscription differentiation, proliferation, migration, and growth of the cell.
- Historical perspective onmechanotransduction research (Frank Booth)
- Develop a gym model for a rat
- Integrin signaling & muscle growth(Marni D. Boppart)
- Concerns
- FAK: linking integrins to mTORC1?(Keith Baar)
- Initial summary
- The potential roles of TSC2 andphosphatidic acid in the mechanicalactivation of mTOR (Troy A. Hornberger)
- Hypothetical model: mechanoreceptor?
- Contraction-induced changes in muscleprotein synthesis: does exercise loadmatter? (Nicholas Burd)
- Time under tension
